Lead Modulation on Adoptive Immune Response in Mice
نویسنده
چکیده
Recipient Swiss albino mice which received sensitized cells from peritoneal exudates (PEC), thymus (T) and bone marrow(BM) were exposed to lead and challenged with human dwarf tapeworm Hymenolepis nana. Oral lead exposure suppressed the immune response as indicatd by low values of different fractions of immunoglobulins and increase in susceptibility to infection at larval and adult developmental stages in passively immunized mice. Both the humoral and cellular components of the immune system have failed to cooperate in the expulsion of worms but recients of snsitized T-cells showed lesser suppression of immune response in comparison to other recipient groups.
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